Smoking in the last 6 months, because smoking may cause a inflammatory responses.Clinically significant laboratory abnormalities other than CRP.No prior diagnosis of drug or alcohol dependence. Subjects will have met DSM-IV criteria for recurrent MDD in a current major depressive episode. No prior diagnosis of drug or alcohol dependence.As secondary goals, we will assess 1) the effects of medication treatment in the MDD patients and 2) the relationship between CRP levels and TSPO binding in both MDD patients and healthy subjects. As the primary goal, we will compare VT values obtained in MDD subjects with those from healthy controls. To assess absolute quantitation of TSPO with 11C-PBR28, we will primarily use the distribution volume (VT) calculated with compartmental modeling. We will try to minimize the recruitment of new healthy controls by relying on our historical database of healthy controls already scanned with PBR28.
We will exclude subjects (approximately 10% of the population) that have low affinity for PBR28 ( non-binders ), based on a blood test or genotyping.Īll healthy volunteers must not have any current serious medical condition.įor absolute quantification of TSPO, both MDD subjects and healthy controls will have arterial blood sampling concurrent with PET imaging using 11C-PBR28. The remaining 10 MMD subjects included in the total - account for subjects who sign consent (and therefore contribute to the accrual ceiling) but do not complete the study for a variety of reasons.Ībout half of the MDD subjects will be taking antidepressant medication and half will be unmedicated. We will recruit up to 40 MDD subjects to achieve 30 completers. This protocol will study up to 40 patients with MDD and 30 healthy volunteers. The aim of this study is to assess whether subjects with MDD have increased TSPO binding in brain as an indirect marker of neuroinflammation. This protein can be accurately quantified using positron emission tomography (PET) and PBR28, a TSPO tracer synthesized in our laboratory. TSPO is, thereby, a potential biomarker of neuroinflammation. Translocator protein 18 kDa (TSPO) is a highly expressed protein in inflammatory cells of the brain: activated microglia and reactive astrocytes in brain. Moreover, patients treated with cytokines for various illnesses are at increased risk of developing MDD. For example, MDD (even in the absence of medical illness) is often associated with raised inflammatory markers, and inflammatory medical illnesses are associated with greater rates of MDD. Inflammation in the periphery and in brain may be a predisposing factor for major depressive disorder (MDD). Treatment will not be provided as part of this study.This scan will take pictures of the brain for comparison studies. Participants will also have an MRI scan.This scan will look for possible brain inflammation. They will have a dose of the contrast agent before the study. Participants will have a PET scan after the screening visit.They will provide blood samples before the scanning sessions. Participants will be screened with a physical exam and medical history.Individuals at least 18 years of age who have major depressive disorder. To see if people with major depressive disorder have increased inflammation in the brain. To do so, they will use a contrast agent, which is a chemical that can show inflammation during an imaging study. Researchers want to use magnetic resonance imaging (MRI) and positron emission tomography (PET) scanning to study inflammation in the brain. Brain inflammation may contribute to depression, and may make it more difficult to treat some kinds of depression with current therapies. Studies have shown that inflammation plays an important role in depression. Why Should I Register and Submit Results?.
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